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Active Ingredient: Gabapentin

Neurontin is an antiepileptic agent that prevents an abnormal surge of electrical activity in one or more areas of the brain.

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This content has been written and checked for quality and accuracy by
Dr. Thomas Kelly (updated on: 25/06/2020)

What is Neurontin?

Neurontin is a drug based on Gabapentin, which has long been known and well-proven as an anticonvulsant and analgesic for neurotic pain.


Form release

Generic Neurontin is sold in packages of 10 capsules, packaged in two cell contour stickers of 5 solid gelatin capsules. Their opaque shell is orange with dark blue ink inscriptions. Inside the capsules-grayish-blue or white powder. 1 therapeutic dose contains:

  • gabapentin-300 mg
  • lactose-up to 75 mg
  • starch-30 mg
  • talc-30 mg.

Pharmacological action

This is a drug with a targeted anticonvulsant effect. The active substance (Gabapentin) is similar in molecular structure to gamma-aminobutyric acid, which is an inhibitory neurotransmitter. However, Gabapentin does not work like other similar drugs that affect the corresponding "inhibitory" receptors. A lot of people write that it gives you a burst of energy, in youth slang – "hangout". What is the reason for this?

Why does this drug affect everyone differently?

This is because this drug affects GABA structures, and not the systems dependent on epinephrine, norepinephrine, or serotonin. Therefore, it can be excitable or sedative, it is unpredictable and depends on the individual, on which type of nervous system prevails in this individual – sympathetic or parasympathetic.

On the other hand, gabapentin can be used to smoothly give up heavy drugs like "Lyrica". Gradually reducing the dosage over a month is enough for this.

What is treated with Neurontin?

The drug is prescribed for adults and children over 12 years of age in the form of monotherapy. Neurontin prepartum is used to treat:

  • epilepsy
  • neurological pain
  • restless leg syndrome
  • neuralgia
  • sciatica
  • diabetic neuropathy
  • alcohol withdrawal syndrome
  • anxiety disorders
  • depression, etc.

The first main indication for the appointment of Neurontin is epilepsy, its various types. It can be generalized, local, partial, and so on. There are dozens of types of epilepsy, and this disease is treated by neurologists. Unfortunately, you have to fight epilepsy for life, because it doesn't go away. Ideally, the treatment of epilepsy (cryptogenic epilepsy) should be monotherapy with a single drug that allows you to avoid attacks. Because every attack is life-threatening – a person is convulsed, stops breathing, loses consciousness, may fall from a height at this time, etc. And Neurontin is perfect in this regard.

World Epilepsy Statistics

The second main indication for taking Gabapentin is chronic neuropathic pain. As a rule, we are talking about Koch's diabetes, severe degradation of the nervous system. This is more than unpleasant pain, pain like "wet socks", burning, difficult to bear, and not stopped. Conventional painkillers in the treatment of such pain syndromes do not work. Neurontin has proven itself well in long-term use. A neurologist also works here, and it is this doctor who prescribes the drug.

Some neurological pains can kill the will to live, for example, after spinal injuries. The cruel paradox is often that painful shocks like electrical discharges are felt by people in places that have lost their normal sensitivity due to paralysis. Such pains torment people for years, and it is impossible to get rid of them without the help of serious medical drugs. One of the most effective is Generic Neurontin.

But there are conditions when the drug is prescribed by a psychiatrist. At the same time, some doctors consider all research to prove the therapeutic effect in psychiatry controversial and "far-fetched". Although the drug is not a dummy and works perfectly as an anticonvulsant.

Neurontin: side effects

Often, both doctors and patients do not pay attention to such side effects of the drug as euphoria, which occurs when the therapeutic dose is exceeded. But many addicts who used opiates immediately noted an increase in the intoxicating effect.

Some patients had negative effects even when taking therapeutic doses:

  • fatigue
  • loss of libido
  • myalgia
  • urinary incontinence
  • ringing in the ears.

Also, a meta-analysis in 2010 confirmed an increased risk of suicide in individuals who took gabapentin against the background of corresponding mental disorders.

Use in psychiatry

Let's look at how Neurontin behaves in monotherapy, i.e. treatment with a single drug for conditional anxiety-depressive neurosis. With psychotic disorders, everything will be completely different. Secondly, in the most typical situations that are most often encountered in practice. You or your loved ones may have very different effects due to the individual characteristics of your body.

Impact on the cognitive sphere

Neurontin has the most positive effect on the cognitive sphere, if compared with other drugs (carbamazepine, etc.), it is more targeted, pinpoint. It only affects certain Delta subunits of calcium channels, and that's it.

It does not capture other channels, so there are no big side effects, blurring of consciousness, and changes in the surrounding reality. If you take Carbamazepine, then in certain indications it is good, but sometimes "hits the sparrows with a gun". Gabapentin, on the contrary, is more accurate (like a rifle against a gun), hits small targets, so it practically does not cause side effects.

In the cognitive sphere, as with other anticonvulsants, there is no change in perception, distortion of sensations – both auditory and visual, including aesthetic. There is no slowing down of thinking, associative process, synthetic and analytical operations, everything functions normally. Even on the contrary, sometimes some stabilization is noted.

Influence on the emotional sphere

As for the emotional sphere, everything is even better here.

Normotimic effects are almost present in two groups of major psychotropic drugs. To nonmathematical are anticonvulsant medications and typical antipsychotics. However, not every anticonvulsant drug is normothermic. This applies to Gabapentin, but it has pronounced normotimic effects, as side effects.

Even though gabapentin is not an antidepressant, and is not, unlike the same carbamazepine, dopamine-positive, for some reason It also has a positive effect on the emotional sphere, i.e. it acts antidepressant.

Many people note that under the influence of Neurontin, the "rocking of emotions" stops, when one state changes abruptly, for no apparent reason, to another. When the elated mood is quickly replaced by a state of depression, and Vice versa.

Additionally, under the influence of generic Neurontin, a slightly elevated mood occurs, which makes a person stay afloat, increases his performance, and improves his physical condition.

Influence on the behavior

In the behavioral sphere, there is also a serious influence on Neurontin. Most drugs that work in this area are sharply divided into either sedative or stimulating. Take, for example, the sedative Amitriptyline or the stimulating Imipramine. The vast majority of such drugs have a balanced anti-anxiety, sedative, and somewhat stimulating effect, which is exactly what is required for many mental disorders there is no.

Generic Neurontin online

The required drugs are quite small, balanced not only for medical reasons but also for the actual mental effects that they produce. So that there is no blurring and slowing down of the cognitive sphere on the one hand, but also no excitement or acceleration of cognitive and emotional processes on the other hand. Gabapentin just refers to these few drugs that have a balanced effect.

Neurontin has both anti-anxiety, sedative, and somewhat stimulating effects, but the drug does not lead to the fact that the cognitive sphere begins to function worse. As with the same Paroxetine, which has a powerful anti-anxiety and anti-depressive effect, but the cognitive sphere under its influence functions in a completely different way, not to say that it is completely bad, but differently, abnormally.

Neurontin, in addition to its direct normotimic effect, has satellite effects:

  • anti-anxiety
  • antidepressant
  • stimulating.

They make the human condition quite effective. People who were previously treated with powerful antidepressants for asthenia, i.e. asthenic depression, began to feel a significant improvement when Gabapentin was added.

Behavioral effects are also balanced, there is no great need to communicate with everyone at once. Or, as with other drugs, the desire to leave people somewhere far away, to stay alone, to be alone, to think.

Against the background of balanced action, a noticeable anti-anxiety effect of Neurontin stands out. There is a desire to communicate, but it is not overactivity or hyperactive sociability, as, on serotonin antidepressants, it is selective sociability.

The motivation for activity is also well stimulated. this is generally understood as the motivation of any activity, not just professional. This is why psychotherapists try to add Neurotin to antidepressants. With it, people suffering from asthenic depression feel much better. What previously seemed to such people generally something unaffordable and unreal, with Neurontin is done automatically, spontaneously, easily, at ease, and everything turns out very well. Ie, the motivation for activity increases significantly and has a very beneficial effect on the person.

Why do drug addicts like gabapentin and drug psychiatrists dislike it?

Many people think that Neurontin is a new drug that will blow up the market. They say that it replaced Lyrica, which has become habitable for decades in our pharmacological market and was wildly popular with drug addicts. The number of fans of this drug is especially high among residents of the South of the Russian Federation. But in fact, the opposite is true, and Neurontin is far from new.

The substance Gabapentin itself was developed back in 1975. It went on sale in pharmacies in the UK in 1993, and 1994 – in the United States. Now on the market, there are a large number of generic drugs and their analogs with the active substance Gabapentin. It is an altered molecule of gamma-aminobutyric acid under the international name "GABA". This is our main inhibitory neurotransmitter. However, the drug molecule does not affect gamma-aminobutyric acid and does not bind to its receptors. The effect of neurontin is not particularly studied. Why do this if the substance is very popular and sells well?

Our statistics show that with all the diversity of the American drug market, 20% of addicts had a history of abuse of Gabapentin. But everyone always wants something new, and pregabalin "Lyrica" came out on the drug market. It has greater bioavailability than its predecessor. As a result, pregabalin acts 2.5 times more strongly than Gabapentin and also has 6 times more pronounced analgesic effect.

When it became difficult to buy Lyrica, the addicts switched to using Neurontin. Both as monotherapy and together with codeine-containing drugs. Yes, all this is sold by prescription. But someone easily gets out of the situation, because now the cities of Russia are filled with empty recipes. It is not easy to buy Lyrica, but neurontin is easy, and addicts solve their problems by increasing the dose of the drug because It is weaker.

As a result, drug users did not find anything new in Neurontin. They returned to the old substance, weaker, which is why they have to significantly increase the dosage. Therefore, it is now easier to get poisoned. This is why this "light drug" should be taken seriously.

You should pay special attention to minors.

Symptoms of drug intoxication with neurontin are as follows:

  • vertigo
  • lack of coordination
  • drowsiness
  • weakness
  • wobbly gait
  • blurred speech.

Naturally, the child invents some disease or poisoning to justify this condition. The task of adults is to be objective because pharmacy tests are unreliable in such cases.

The active substance generic Neurontin in an overdose of 3 or more times provides a very wide range of side effects, which are very popular with addicts. Using about 1000 mg of neurontin (a three-fold overdose), a person gets the characteristic euphoric, relaxing effect of drugs, some people have hallucinations.

At the same time, few of the "pharmacy" addicts realize at first that they are getting into real drug addiction. People think that if the drug is sold in a pharmacy, they received it according to the official prescription of a real doctor, and the medicine is made in state factories, then the drug is safe and you can use it without any fears.

As a result of careless handling of Neurontin (regular overdoses), such negligent patients risk being registered with a narcologist, as well as standard drug users who use substances that are prosecuted.

Conclusion

A well-proven anticonvulsant drug based on the active substance Gabapentin is also effective against various neurological pain. But it requires strict compliance with the dosage. Otherwise, good medicine can turn into narcotic poison.



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